OPEN SOURCE BIOLOGY

A Collective Movement to Neutralize COVID-19

HOW IT WORKS

03

Get sequences

Receive genetic sequences of the nanobodies within 24 hours of becoming an approved CCC19 Pledgor.

 

ABOUT THE

MOVEMENT

OUR STORY

CCC19.ca's goal is to eliminate the barriers to blockbuster nanobodies and drive the development of scientific data, accurate

diagnostics, and efficacious therapeutics through cost-free licenses to all those that want to be part of the global movement.

OUR VISION

We want to catalyze solutions for COVID-19 in an equitable model to complement the vast global effort underway and allow all stakeholders to benefit without leaving any group or patient behind.

THE TECHNOLOGY

A single-domain antibody (sdAb), also known as a nanobody, is an antibody fragment consisting of a single monomeric variable antibody domain.  Due to their small size, they can be easily and cost-effectively scaled-up using common bioproduction methods.

 
 

THE 

FOUNDERS

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                Cedarlane

The company offers a myriad of biologicals and biochemicals to Life Science researchers and clinicians providing products from virtually all of the world’s most renowned international manufacturers.  Cedarlane provides a gateway to over two million global reagents. Customers have the advantage of freight consolidation, and the convenience and cost savings inherent within. Manufactured products include monoclonal and polyclonal antibodies, cell separation media, a complement for tissue typing, and highly characterized neuronal cell lines. Visit http://www.cedarlanelabs.com

           Natural Products Canada

Natural Products Canada (NPC) is the driving force behind Canada’s Natural Product Innovation Cluster–a strategic community of SMEs, research institutes, corporations, investors, government departments, and service providers who support the development and commercialization of naturally-derived products and technologies in health and life sciences, natural resources, agriculture and agri-food, and sustainable bioproducts. NPC has over 600 opportunities in its pipeline, has completed ten investments, and has already experienced two exits. Visit www.naturalproductscanada.com

                NovoBind Livestock Therapeutics

NovoBind develops products that meet the growing global demand for increased food production without the use of antibiotics and antimicrobial chemicals. Their next-generation biologics target and neutralize devastating pathogenic bacteria, viruses, and parasites that cause $22 billion (USD) in aggregate annual loss to producers in the poultry, shrimp, and companion animal sectors. NovoBind is currently expanding its technology platform to address other sectors of food production, including crop health.  Visit www.novobind.com, covid@novobind.com

           SignalChem Lifesciences Corporation

SignalChem Lifesciences Corporation is a Canadian company focused on the research, development, and production of innovative and high-quality human recombinant cell signaling products. SignalChem strives to support scientists in academia, pharma, and biotech companies around the world by creating effective research tools to advance the basic research in life sciences and to facilitate the efforts in drug discovery and development. 

Visit www.signalchem.com, info@signalchem.com 

                Wilson Sonsini Goodrich & Rosati

Partners in Discovery and Innovation, law firm Wilson Sonsini has one of the largest life sciences practices in the world. For more than 60 years, our attorneys have worked closely with scientists, entrepreneurs, and investors who have helped develop new and innovative discoveries in nearly every field of medicine and healthcare, from genomics, immuno-oncology, and pharmaceuticals, to diagnostics and synthetic biology.

Visit https://www.wsgr.com/en/

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‘AeroNabs’ Promise Powerful, Inhalable Protection Against COVID-19. University of California San Francisco. August 11, 2020

An ultra-high affinity synthetic nanobody blocks SARS-CoV-2 infection by locking Spike into an inactive conformation. M. Schoof et al. bioRxiv /10.1101/2020.08.08.238469. 

 

Baofu Qiao et al.  Enhanced Binding of SARS-CoV-2 Spike Protein to Receptor by Distal Polybasic Cleavage Sites. ACS Nano Article ASAP, DOI: 10.1021/acsnano.0c04798

Hyeonuk Woo et al, Developing a Fully-glycosylated Full-length SARS-CoV-2 Spike Protein Model in a Viral Membrane, The Journal of Physical Chemistry B (2020). DOI: 10.1021/acs.jpcb.0c04553

Wrapp et al.  Structural Basis for Potent Neutralization of Betacoronaviruses by Single-Domain Camelid Antibodies. Cell 181, 1004–1015 May 28, 2020

Wrapp, D. et al. Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation. Science (80-. ). eabb2507 (2020) doi:10.1126/science.abb2507.

Tiwari, P.M., Vanover, D., Lindsay, K.E. et al. Engineered mRNA-expressed antibodies prevent respiratory syncytial virus infection. Nat Commun 9, 3999 (2018). https://doi.org/10.1038/s41467-018-06508-3


Zhao, G. et al. A Novel Nanobody Targeting Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Receptor-Binding Domain Has Potent Cross-Neutralizing Activity and Protective Efficacy against MERS-CoV. J. Virol. 92, e00837-18 (2018).

Stalin Raj, V. et al. Chimeric camel/human heavy-chain antibodies protect against MERS-CoV infection. Sci. Adv. 4, eaas9667–eaas9667 (2018).

*Trademarked by Ablynx, otherwise known as single-domain antibodies, llama antibodies, VHH, VNAR

 

JOIN THE

MOVEMENT

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Earth

NEWS

CONTACT

#900, 1021 West Hastings St.
Vancouver, CanadaSan Francisco, CA 94158
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©2020 by Canadian Coalition for COVID-19